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. 2017 Aug 4;7:7264. doi: 10.1038/s41598-017-07585-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential expression of genes involved in energy metabolism. Genes encoding proteins that function in (A) regulation of energy metabolism, (B) glucose metabolism, (C) fatty acid metabolism, and (D) regulation of ATP and substrate utilization were identified by Gene Ontology analyses and/or by PubMatrix analyses of genes with an FDR < 0.05. RPKM values for WT (black bars) and AE3-null (white bars) hearts are shown. Genes encoding proteins that are regulated by Akt are indicated (Akt). The genes shown are a subset of 142 genes in Supplementary Table S4; values are means ± SE; n = 4 for each genotype; *p ≤ 0.01 vs WT controls.