Figure 7.

Endophilin B2 attenuates expression of macrophage differentiation and activation genes. The mRNA levels of (A) Siglecf, (B) Itgax, (C) Itgam, and (D) Spi1, (E) Nos2, and (F) Arg1 in WT and B2−/− mice were quantitated by qRT-PCR in total lung. Data were normalized to 18S rRNA and expressed as relative quantity (RQ) compared to WT uninfected control treated with DPBS vehicle. ***p < 0.00001, **p < 0.001, *p < 0.05 (for WT n = 4, 9, 8, and 6 and B2−/− n = 3, 7, 8, and 6 at t = 0, 3, 7, and 14 days; the vehicle treated mice are plotted as t = 0. Data ± SEM are from 2 independent experiments).