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. 2017 Aug 4;7:7342. doi: 10.1038/s41598-017-07191-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of CLEAR score and mutation in TCGA cohort. (A) Individual correlation between tumor CLEAR score with tumor grade, stage and size distribution as well as mutation status are presented. The correlation of CLEAR score and TCGA grade, stage was investigated by ANOVA (p = 7.769e-09, p = 3.22e-08, respectively); the correlation of CLEAR score and TCGA sample size was estimated by spearman correlation (p = 4.252e-09). (B) Boxplots of CLEAR score distribution of samples with relevant gene mutations. The dashed line represents the median CLEAR score of the 414-sample set. Samples with mutated BAP1, TP53, PTEN and MTOR are associated with higher CLEAR scores (Mann–Whitney U test, *p ≤ 0.05, **p ≤ 0.001”).