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. 2017 Aug 4;7:7328. doi: 10.1038/s41598-017-06767-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased levels of long-chain acylcarnitines were detected maximally in the early stage (H&Y stage I) of Parkinson’s disease (A,B). Levels of muscular metabolites, long-chain acylcarnitines, and long-chain FAs of each Parkinson’s disease H&Y stage in each cohort are summarized in each heat map. Abbreviations: AC = acylcarnitine; H&Y = Hoehn and Yahr stage; FA = fatty acid.