Table 2.

Statistically significant metabolites in Parkinson’s disease vs controls in both cohorts.

Compound	Comparative Analysis
	Parkinson’s disease/Control
	1st Cohort		2nd Cohort
	Ratio	P-valuea	Ratio	P-valuea
3-Methoxytyrosine	232	<0.0001	140	<0.0001
Indole-3-acetic acid	0.675	<0.0001	0.626	<0.0001
Urea	1.16	<0.0001	1.22	<0.0001
Homovanillic acid	1.34	<0.0001	1.28	<0.0001
Guanidinosuccinic acid	1.41	0.00204	1.32	0.0013
Cortisone	1.12	0.0387	1.50	<0.0001
Trigonelline	0.728	<0.0001	0.657	0.0023
Oleoylethanolamine	1.21	0.00431	1.13	0.0129
Palmitoylethanolamine	1.15	0.00175	1.09	0.0168
Citric acid	1.17	0.00187	1.07	0.0252
Deoxycholic acid	1.83	0.0402	2.60	<0.0001
AC(12:0)	0.505	<0.0001	0.675	0.0146
AC(12:1)	0.546	<0.0001	—	—
AC(12:1)-1	—	—	0.762	0.0176
AC(12:1)-2	—	—	0.632	0.0003
AC(14:0)	0.532	<0.0001	0.766	0.0252
AC(14:1)	0.662	0.0043	0.72	0.0173
AC(14:2)	0.628	<0.0001	0.735	0.0187
AC(16:0), Palmitoylcarnitine	0.543	<0.0001	0.767	0.0205
AC(16:1)	0.582	<0.0001	0.824	0.0421

Abbreviations: AC = acylcarnitine.

^a P-value obtained by Wilcoxon’s test, comparing between PD and controls.