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. 2017 Aug 4;7:7345. doi: 10.1038/s41598-017-07433-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathologic changes in the lungs of immunocompetent and immunocompromised mice inoculated with influenza B viruses. BALB/c, NOD scid, and BALB scid mice were inoculated with viruses as described in the legend for Fig. 2. Pulmonary lesions were evaluated at 6 dpi (n = 4/virus/mouse strain). The panels show the extent of virus infection and histopathology of influenza MA/12, PH/13, and BR/08 viruses in the lungs of immunocompetent BALB/c (a,d,g) and immunocompromised NOD scid (b,e,h) and BALB scid (c,f,i) mice. A representative section is shown for each virus and mouse strain. The green lines designate total lung areas measured; red-shaded areas designate bronchioles/alveoli with active virus infection (i.e., containing antigen-positive epithelial cells). The average percentage of the total lung field containing antigen-positive epithelial cells are shown in red texts and the average severity score ± SE for inflammation are shown in black texts. *P < 0.05, relative to BR/08 scores, as determined by one-way ANOVA with Bonferroni’s multiple comparison post-test.