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. 2017 Aug 4;7:7353. doi: 10.1038/s41598-017-07659-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of QSYQ and QSYQ-DO on cardiac enzyme release and myocardial histology. (A) CK-MB and LDH release in serum of DOX-treated mice, (B) Representative images showing H&E staining of heart sections (400 × magnification), and (C) Representative photomicrographs of TUNEL staining images. Total nuclei were labeled with DAPI (blue) and apoptotic nuclei were detected by TUNEL staining (green). One of 8 similar images was shown. All scale bars are 50 μm. Data are expressed as mean ± SD, n = 8. ^##p < 0.01 vs. Control group. *p < 0.05 vs. DOX group.