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. 2017 Aug 4;7:7311. doi: 10.1038/s41598-017-07125-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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N-WASP knockout in keratinocytes leads to dry skin. (A) Western blot analysis for N-WASP expression in skin epidermis (P19 and P23), brain and lung from P23 mice (n = 3) (N-WASP^K14KO and N-WASP^fl/fl), (Blots were cropped and full length western blot images are in supplementary Fig. S6A), (B) Average body weight of represented mice, (n = 5) (C) Dry, wrinkled and scaly skin in N-WASP^K14KO mice; Skin from control and N-WASP knockout mice on P4, (CI), P19 (CII) and P23 (CIII) (n = 20). (D) Atopic dermatitis features in adult N-WASP^K14KO skin; Nevi on skin (DI), severe atopic like skin (DII), (↑) indicates lymph node swelling (DIII), and (↑) indicates inflammation (DIV) (n = 20) in N-WASP^K14KO mice skin. Results are mean ± SEM ***p < 0.001.