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. 2017 Aug 4;7:7311. doi: 10.1038/s41598-017-07125-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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N-WASP knockout in keratinocytes causes a defect in epidermal barrier function. (A) Tewameter analysis showed increased transepidermal water loss (TEWL) in N-WASP^K14KO mice skin compared to control mice on P15, P23, P30, P60 and P120 day (n = 6). (B) Enhanced penetration of Lucifer Yellow into the skin of N-WASP^K14KO mice compared to skin of control mice. (C) Western blot analysis showed comparably reduced filaggrin expression in N-WASP^K14KO mice skin compared to control mice on P3, P25, P120 and P180 (n = 3). Results are mean ± SEM ***p < 0.001, **p < 0.01.