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. 2017 Aug 4;7:7311. doi: 10.1038/s41598-017-07125-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Development of local and systemic inflammatory responses in N-WASP^K14KO mice. Cytokine analysis showed higher levels of IL-1α (A-1) and TNF-a (A-2) in skin and as well as in serum (B and C), IL-6 (D) and IL-17 (E) cytokines in serum of N-WASP^K14KO compared to control mice on 23^rd day. Similarly, chemokine analysis showed significantly increased levels of G-CSF (F), KC (G) and eotaxin (H) chemokines in serum of N-WASP^K14KO mice compared to control mice on 23^rd day. (I) Western blot analysis of whole skin protein lysate showed that expression of PDGFR and FGF-7 are increased in N-WASP^K14KO compared to P23 control mice (Blots were cropped and full length western blot images are in supplementary Fig. S6C). Immunostaining showed that both PDGFR (J) and FGF-7 (K) are significantly increased in skin of N-WASP^K14KO mice compared to control mice (P23 mice). Results are mean ± SEM ***p < 0.001, **p < 0.01, *p < 0.05 (n = 8).