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. 2017 Aug 4;7:7305. doi: 10.1038/s41598-017-07848-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PF-06747143 inhibits CXCL12-driven migration of leukemic cell lines and primary AML cells from patients. (A) Cell surface CXCR4 of U937 and HL-60 was measured by flow cytometry with PF-06747143 and 12G5 antibodies. (B,C) Effect of PF-06747143 (10 μg/ml), IgG1 (10 μg/ml), AMD3100 (20 μM) or TN140 (5 μM) on chemotactic responses to 100 ng/ml CXCL12. Leukemic cell lines (B), primary AML cells (C). **P < 0.01(student’s t-test).