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. 2017 Aug 4;7:7273. doi: 10.1038/s41598-017-07839-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of regional cerebral blood flow (rCBF) in Nptn ^{loxloxEmx1Cre} brain. Compared to control Nptn ^lox/lox mice, brain areas with increased rCBF in Nptn ^{loxloxEmx1Cre} mice are indicated in red (Increase, left column) and with decreased rCBF in blue (Decrease, middle column). rCBF in mutant mice was scored as % of change relative to control mice. P-values Map (right column) scores changes in rCBF according to their statistical significance level in the color-ranged bars from P < 0.01 to P < 0.001. R, right brain hemisphere. L, left. Distances from bregma are indicated (−0.2, −1.4, and −3.2).