Skip to main content
. Author manuscript; available in PMC: 2017 Aug 5.
Published in final edited form as: Jpn J Ophthalmol. 2016 Jul 5;60(5):408–418. doi: 10.1007/s10384-016-0461-1

Fig. 1.

Fig. 1

Illustration of the mechanism of redox regulation by perox-iredoxin 6 (Prdx6). Prdx6 detoxifies and controls intracellular levels of reactive oxidative species (ROS), providing cytoprotection by maintaining survival signaling. The active site cysteine (Cys47) is oxidized to cysteine sulfenic acid (Cys47-SOH) by hydrogen peroxide (H2O2). However, the resulting Cys47-SOH cannot form a disulfide bond because no other Cys-SH residues are present nearby. Cys47-SOH can be reduced by nonphysiologic thiols. Occasionally, the sulfenic intermediate is hyperoxidized to sulfinic (Cys-SO2H) or sulfonic (Cys-SO3H) acid, inactivating its peroxidase activity. GST Glutathione-S-transferase, UV-B ultraviolet B