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. Author manuscript; available in PMC: 2017 Aug 5.
Published in final edited form as: Adv Pharmacol. 2016 Mar 24;76:103–145. doi: 10.1016/bs.apha.2016.01.004

Figure 3. Schematic representation of the signaling pathways that regulate transcription of GLT-1/EAAT2/SLC1A2.

Figure 3

Figure 3

Several signaling pathways activated in response to extracellular molecules regulate the expression of GLT-1 by activating transcription factors that interact with cis elements in the promoter. The pathways that increase or decrease GLT-1 transcription are depicted in different schematics (Panel A & B, respectively). For a detail description see the text. TX: tamoxifen, E2: estrogen, AC: adenylate cyclase, GR: glucocorticoid receptor, MR: mineralocorticoid receptor.