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. 2017 Jul 12;199(4):1465–1475. doi: 10.4049/jimmunol.1602151

FIGURE 7.

FIGURE 7.

NADA regulates neuropeptide release via TRPV1 in endotoxemic mice. WT and Trpv1−/− mice were challenged i.v. with LPS or carrier for LPS (normal saline) and then immediately treated i.v. with NADA (10 mg/kg) or vehicle for NADA. Substance P (A) and CGRP (B) levels were quantified in plasma at 2 h (n = 4–6 mice per group). The Mann–Whitney U test was used to calculate statistical significance. *p < 0.05, LPS-treated WT mice in the presence or absence of NADA. #p < 0.05, WT mice treated with carrier alone versus WT mice treated with LPS alone or NADA alone, or mice treated with NADA versus mice treated with LPS and NADA. δp < 0.05, Trpv1−/− mice treated with carrier alone versus mice treated with LPS alone, or Trpv1−/− mice treated with NADA alone versus mice treated with LPS + NADA. NS, no significant between LPS-treated Trpv1−/− mice in the presence and absence of NADA.