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. 2017 Aug 4;14:156. doi: 10.1186/s12974-017-0930-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Exogenous BDNF exerts biological effects following intracerebroventricular delivery. a Experimental procedures. b Rats were weighed from the first day of pretreatment. The body weight of BDNF-pretreated rats increased slowly through day 4, at which time their weight was significantly lower as compared with that of rats in the PBS + PM group. *p < 0.05, BDNF + PM group compared with the PBS + PM group