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. 2017 Aug 4;14:156. doi: 10.1186/s12974-017-0930-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — BDNF inhibited MyD88 expression in PM. MyD88 mRNA levels in the a hippocampus and b cortex increased at 24 h post-infection. BDNF pretreatment inhibited the upregulation of MyD88 mRNA, whereas rats pretreated with k252a showed increased MyD88 expression as compared with that observed in the BDNF + PM group. Western blot analysis confirmed lower levels of MyD88 protein in the c, e hippocampus and d, f cortex following BDNF treatment, whereas these results were not observed in the k252a + PM group. **p < 0.01