Table 1.
Variables included in the Frailty Index
| Nr. | Variable | Deficit description |
|---|---|---|
| 1 | Hypertension | Measured blood pressure or on treatment |
| 2 | Diabetes mellitus type II | Fasting glucose >125 mg/dL or on treatment |
| 3 | Chronic kidney disease | Two estimated glomerular filtration rate measurements <60 mL/min/1.73 m2 |
| 4 | Osteopenia/Osteoporosis | Osteopenia: dual-energy X-ray absorptiometry (DEXA) Tor Z score <−1.5 or Osteoporosis: DEXA Tor Z score <−2.5 or fragility fracture |
| 5 | Any cancer | Clinical diagnosis |
| 6 | High or low BMI | <18 or >25 kg/m2 |
| 7 | High total cholesterol | >200 mg/dL |
| 8 | High triglycerides | >150 mg/dL |
| 9 | Leucopenia | <4000 cells/µL |
| 10 | Anemia | If female: <10 g/dL If male: <12 g/dL |
| 11 | Low platelets | <150 billion/L |
| 12 | Hyponatremia | <125 mEq/L |
| 13 | Abnormal potassium | <3.5 or >5.3 mEq/L |
| 14 | Elevated aspartate transaminase | >31 U/L |
| 15 | Elevated alanine transaminase | >31 U/L |
| 16 | Abnormal alkaline phosphatase | <38 or >126 U/L |
| 17 | Elevated γ-glutamyl transphosphatase | >55 U/L |
| 18 | Elevated total bilirubin | >1.10 mg/dL |
| 19 | Elevated creatinine | If female: >1.0 mg/dL If male: >1.2 mg/dL |
| 20 | Elevated INR | >1.2 |
| 21 | Hepatits C virus viral load | HCV-RNA >12 copies/mL |
| 22 | Hepatitis B coinfection | Pre-LT: positive HBeAg Post-LT: HBV-DNA >copies/mL |
| 23 | Epstein-Barr virus coinfection | Pre-LT: positive EBV IgG Post-LT: HBV-DNA >copies/mL |
| 24 | Cytomegalovirus coinfection | Pre-LT: CMV IgG Post-LT: HBV-DNA >copies/mL |
| 25 | HIV viral load | >40 copies/µL |
| 26 | Current CD4+ cell count | <500 cells/µL |
| 27 | CD4+/CD8+cell ratio | <1 |
| 28 | Nadir CD4+ cell count | <200 cells/µL |
| 29 | History of AIDS | History of CDC category C HIV disease [38] |
| 30 | Duration of HIV infection at LT | >20.6 years |