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. Author manuscript; available in PMC: 2017 Aug 6.
Published in final edited form as: Reprod Toxicol. 2015 Jul 29;58:33–44. doi: 10.1016/j.reprotox.2015.07.075

Table 1.

Number of animals/treatment group assigned to the interim (1 year) and terminal (2 year) sacrifices of the core chronic BPA toxicity study.a

Group Arm (Continuous/Stop) 1 Year 2 Year
Male Female Male Female
Vehicle Continuous 22 23 50 50
Stop 20 20 50 50 (49)b
2.5 BPA Continuous 22 22 48 48
Stop 20 22 48 50
25 BPA Continuous 20 22 48 46
Stop 20 20 48 48
250 BPA Continuous 24 24 50 50
Stop 20 22 50 50
2500 BPA Continuous 20 20 50 50
Stop 20 20 50 50
25,000 BPA Continuous 22 24 46 46
Stop 22 22 46 46
0.05 EE2 Continuous 26 26 26 26
0.50 EE2 Continuous 26 26 26 26
a

Animals were allocated to the interim or terminal sacrifice of the continuous or stop dose arms of the study at weaning. There were no same sex litter mates in any treatment group. The original protocol indicated 26 animals/sex/treatment group for the interim sacrifice and 50 animals/sex/BPA treatment group (26 for EE2 groups) for the terminal sacrifice. A shortfall in the number of pups available for the specialty studies resulted in a change such that 20–26 animals/sex/treatment being allocated to the interim sacrifice and any extra pups were allocated to specialty studies.

b

In this group, one animal assigned was found to have been incorrectly sexed and was discarded on the day of allocation.