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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2017 May 31;16(8):1456–1469. doi: 10.1158/1535-7163.MCT-16-0788

Figure 3. VE822 protein regulation, radiosensitization, and toxicity.

Figure 3

a. Western blot of phospho-Chk1 levels in non-radiated (left three columns) and irradiated (right three columns) SF188 cells (top 2 rows) and DIPG spheroids (bottom two rows) with 24h pre-treatment with free VE822 (columns 2 and 5), VE822-NP (columns 3 and 6), or no treatment (columns 1 and 4). Smc1 used to normalize for protein levels. b. Clonogenic survival assay in colony-forming pediatric glioma cells, KNS42 using either VE822-NPs (red) or DMSO control (black) c. Dose-dependent SF188 cell viability at 72h following treatment with free VE822 (red), VE822-NPs (green), or DMSO control (blue).