Table 3.

Current available guidelines addressing antiplatelet therapy for peripheral arterial disease

Class of recommendation	Guidelines
Class Ia	Aspirin in daily doses of 75 to 325 mg or clopidogrel 75 mg/d is recommended to reduce the risk of MI, stroke, or vascular death in individuals with symptomatic atherosclerotic lower extremity PAD
Class IIa	Antiplatelet therapy is reasonable to manage asymptomatic individuals with an ABI less than or equal to 0.90 to reduce the risk of MI, stroke, or vascular death
Class IIb	Dual-antiplatelet therapy (aspirin and clopidogrel) may be reasonable to reduce the risk of limb-related events in patients with symptomatic PAD after lower extremity revascularization

PAD: Peripheral arterial disease; MI: Myocardial infarction.