Table 2.
First 20 functional enrichments in the network shown in Figure 2 using Biological Process Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways.
| #Pathway ID | Pathway description | Observed gene count | False discovery rate | Matching proteins in your network (labels) |
|---|---|---|---|---|
| BIOLOGICAL PROCESS GENE ONTOLOGY (GO) | ||||
| GO.0010557 | Positive regulation of macromolecule biosynthetic process | 20 | 9.39e-13 | Akt1,Ascl1,Atf3,Bdnf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Mtor, Myc,Pten,Rhoa,Sox11,Stat1 |
| GO.0010628 | Positive regulation of gene expression | 20 | 9.39e-13 | Akt1,Ascl1,Atf3,Bdnf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Mtor,Myc,Pten,Rhoa,Sox11,Stat1 |
| GO.0045893 | Positive regulation of transcription, DNA-templated | 19 | 9.39e-13 | Akt1,Ascl1,Atf3,Bdnf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Mtor,Myc,Pten,Sox11,Stat1 |
| GO.0031328 | Positive regulation of cellular biosynthetic process | 20 | 9.56e-13 | Akt1,Ascl1,Atf3,Bdnf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Mtor,Myc,Pten,Rhoa,Sox11,Stat1 |
| GO.0045595 | Regulation of cell differentiation | 19 | 9.56e-13 | Akt1,Ascl1,Bdnf,Cntf,Creb1,Fos,Klf13,Klf4,Klf5,Mtor,Myc,Pten,Rhoa,Rock1,Rock2,Socs2,Socs3,Sox11,Stat1 |
| GO.0051173 | Positive regulation of nitrogen compound metabolic process | 20 | 9.56e-13 | Akt1,Ascl1,Atf3,Bdnf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Mtor,Myc,Pten,Rhoa,Sox11,Stat1 |
| GO.0006355 | Regulation of transcription, DNA-templated | 23 | 2.09e-12 | Akt1,Ascl1,Atf3,Bdnf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf16,Klf4,Klf5,Klf6,Klf7,Klf9,Mtor,Myc,Pten,Rhoa,Sox11,Stat1,Stat2 |
| GO.0031325 | Positive regulation of cellular metabolic process | 22 | 8.17e-12 | Akt1,Ascl1,Atf3,Bdnf,Cntf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Mtor,Myc,Pten,Rhoa,Sox11,Stat1,Stat2 |
| GO.0007166 | Cell surface receptor signaling pathway | 18 | 9.16e-12 | Akt1,Ascl1,Bdnf,Cntf,Cntfr,Creb1,Fos,Jun,Klf4,Klf6,Myc,Rhoa,Rock2,Socs1,Socs2,Socs3,Stat1,Stat2 |
| GO.0006351 | Transcription, DNA-templated | 20 | 1.03e-11 | Ascl1,Atf3,Creb1,Fos,Jun,Klf1,Klf12,Klf13,Klf14,Klf15,Klf16,Klf4,Klf5,Klf6,Klf7,Klf9,Myc,Sox11,Stat1,Stat2 |
| GO.0010243 | Response to organonitrogen compound | 14 | 1.03e-11 | Akt1,Ascl1,Creb1,Fos,Jun,Klf15,Klf4,Mtor,Myc,Pten,Rhoa,Socs2,Socs3,Stat1 |
| GO.0018130 | Heterocycle biosynthetic process | 21 | 1.03e-11 | Ascl1,Atf3,Creb1,Fos,Jun,Klf1,Klf12,Klf13,Klf14,Klf15,Klf16,Klf4,Klf5,Klf6,Klf7,Klf9,Mtor,Myc,Sox11,Stat1,Stat2 |
| GO.0044271 | Cellular nitrogen compound biosynthetic process | 22 | 1.03e-11 | Akt1,Ascl1,Atf3,Creb1,Fos,Jun,Klf1,Klf12,Klf13,Klf14,Klf15,Klf16,Klf4,Klf5,Klf6,Klf7,Klf9,Mtor,Myc,Sox11,Stat1,Stat2 |
| GO.0048519 | Negative regulation of biological process | 25 | 1.03e-11 | Ascl1,Atf3,Bdnf,Cntf,Cntfr,Creb1,Jun,Klf12,Klf13,Klf14,Klf15,Klf16,Klf4,Klf5,Klf9,Mtor,Myc,Pten,Rhoa,Rock1,Rock2,Socs1,Socs2,Socs3,Stat1 |
| GO.0048522 | Positive regulation of cellular process | 25 | 1.96e-11 | Ascl1,Atf3,Bdnf,Cntf,Cntfr,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Myc,Pten,Rhoa,Rock1,Rock2,Socs2,Socs3,Sox11,Stat1,Stat2 |
| GO.0048523 | Negative regulation of cellular process | 24 | 2.03e-11 | Ascl1,Atf3,Bdnf,Cntf,Cntfr,Creb1,Jun,Klf12,Klf13,Klf14,Klf15,Klf16,Klf4,Klf5,Klf9,Mtor,Myc,Pten,Rhoa,Rock1,Socs1,Socs2,Socs3,Stat1 |
| GO.1901362 | Organic cyclic compound biosynthetic process | 21 | 2.04e-11 | Ascl1,Atf3,Creb1,Fos,Jun,Klf1,Klf12,Klf13,Klf14,Klf15,Klf16,Klf4,Klf5,Klf6,Klf7,Klf9,Mtor,Myc,Sox11,Stat1,Stat2 |
| GO.2000026 | Regulation of multicellular organismal development | 18 | 2.09e-11 | Akt1,Ascl1,Bdnf,Cntf,Creb1,Fos,Jun,Klf13,Klf4,Mtor,Myc,Pten,Rhoa,Rock1,Rock2,Socs2,Sox11,Stat1 |
| GO.0010604 | Positive regulation of macromolecule metabolic process | 21 | 2.21e-11 | Akt1,Ascl1,Atf3,Bdnf,Cntf,Fos,Klf1,Klf12,Klf13,Klf14,Klf15,Klf4,Klf5,Klf7,Klf9,Mtor,Myc,Pten,Rhoa,Sox11,Stat1 |
| GO.0030154 | Cell differentiation | 22 | 1.23e-10 | Akt1,Atf3,Bdnf,Cntf,Creb1,Fos,Jun,Klf1,Klf15,Klf4,Klf5,Klf7,Mtor,Myc,Pten,Rhoa,Rock1,Rock2,Socs1,Socs2,Socs3,Stat1 |
| KYOTO ENCYCLOPEDIA OF GENES AND GENOMES (KEGG) PATHWAYS | ||||
| 4380 | Osteoclast differentiation | 8 | 1.5e-09 | Akt1,Creb1,Fos,Jun,Socs1,Socs3,Stat1,Stat2 |
| 4630 | JAK-STAT signaling pathway | 8 | 2.65e-09 | Akt1,Cntf,Cntfr,Myc,Socs1,Socs3,Stat1,Stat2 |
| 5161 | Hepatitis B | 8 | 2.65e-09 | Akt1,Creb1,Fos,Jun,Myc,Pten,Stat1,Stat2 |
| 5200 | Pathways in cancer | 8 | 7.84e-07 | Akt1,Fos,Jun,Mtor,Myc,Pten,Rhoa,Stat1 |
| 5210 | Colorectal cancer | 5 | 1.52e-06 | Akt1,Fos,Jun,Myc,Rhoa |
| 5206 | MicroRNAs in cancer | 6 | 1.79e-06 | Mtor,Myc,Pten,Rhoa,Rock1,Socs1 |
| 4917 | Prolactin signaling pathway | 5 | 2.47e-06 | Akt1,Fos,Socs1,Socs3,Stat1 |
| 4062 | Chemokine signaling pathway | 6 | 5.66e-06 | Akt1,Rhoa,Rock1,Rock2,Stat1,Stat2 |
| 4510 | Focal adhesion | 6 | 1.15e-05 | Akt1,Jun,Pten,Rhoa,Rock1,Rock2 |
| 4668 | TNF signaling pathway | 5 | 1.15e-05 | Akt1,Creb1,Fos,Jun,Socs3 |
| 5205 | Proteoglycans in cancer | 6 | 1.44e-05 | Akt1,Mtor,Myc,Rhoa,Rock1,Rock2 |
| 5166 | HTLV-I infection | 6 | 4.01e-05 | Akt1,Atf3,Creb1,Fos,Jun,Myc |
| 4921 | Oxytocin signaling pathway | 5 | 5.14e-05 | Fos,Jun,Rhoa,Rock1,Rock2 |
| 4022 | cGMP-PKG signaling pathway | 5 | 6.83e-05 | Akt1,Creb1,Rhoa,Rock1,Rock2 |
| 5164 | Influenza A | 5 | 6.83e-05 | Akt1,Jun,Socs3,Stat1,Stat2 |
| 5132 | Salmonella infection | 4 | 7.69e-05 | Fos,Jun,Rock1,Rock2 |
| 4012 | ErbB signaling pathway | 4 | 9.74e-05 | Akt1,Jun,Mtor,Myc |
| 5215 | Prostate cancer | 4 | 0.000111 | Akt1,Creb1,Mtor,Pten |
| 5168 | Herpes simplex infection | 5 | 0.000114 | Fos,Jun,Socs3,Stat1,Stat2 |
| 4915 | Estrogen signaling pathway | 4 | 0.00013 | Akt1,Creb1,Fos,Jun |