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. 2015 Sep 29;5(9):e648. doi: 10.1038/tp.2015.141

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Copyright © 2015 Macmillan Publishers Limited

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(a) Mean peripheral DAT promoter methylation in AD patients and HCs (mean%±s.d.). AD patients had elevated DAT methylation compared with HCs (P=0.008). (b) DAT methylation predicted DAQ craving in AD patients (r²=0.14, P=0.024), whereas not in HCs (r²=0.043, P=0.43). When comparing regression slopes between these groups, the AD group showed a stronger correlation between DAT methylation and DAQ craving than HCs (Fisher’s z=1.88, P=0.03). AD, alcohol-dependent; DAQ, Desire for Alcohol Questionnaire; DAT, dopamine transporter gene; HC, healthy control.