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. 2016 Jul 12;6(7):e853. doi: 10.1038/tp.2016.118

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Brain regions where cannabinoid 1 receptor (CB₁R) availability covaries negatively with log body mass index (BMI) in patients with food intake disorder (FID). T map of significant negative correlations between CB₁R availability and log BMI in predefined homeostatic and reward-related regions of interest shown at a threshold of P_{FWE-corrected}<0.05 (both on the voxel and cluster levels; n=54). The colored voxel-based statistical parametric mapping (SPM) results of the negative correlations in sagittal (x), coronal (y) and transverse (z) sections are overlaid on a normalized canonical image (ch2better-template) available in the MRICron software. The color bar expresses T-score levels.