Table 2. Peak voxels of brain areas where CB₁R availability covaries negatively with log BMI in patients with FID.

Cluster	Cluster level		Voxel level		Peak voxel MNI coordinates	Anatomical localization
	PFWE-corr	kE	PFWE-corr	T	x y z
1	0.006	1118	<0.001	7.69	6 62 −14	Right medial orbitofrontal cortex
			<0.001	6.72	14 56 −18	Right superior orbitofrontal cortex
2	0.001	3637	<0.001	7.59	−30 12 −20	Left anterior insula
			<0.001	7.29	−30 −2 −28	Left amygdala
			<0.001	7.02	−28 10 6	Left putamen
			<0.001	6.81	−38 −20 2	Left posterior insula
			<0.001	6.76	−8 2 −6	Left globus pallidus
3	0.001	3607	<0.001	7.46	40 12 −16	Right anterior insulaa
			<0.001	7.43	30 4 −28	Right amygdala
			<0.001	7.22	46 −10 2	Right posterior insula
			<0.001	7.16	8 18 −6	Right caudate head
			<0.001	6.60	20 20 −4	Right putamen
			<0.001	6.45	12 2 −6	Right globus pallidus
4	< 0.001	3827	<0.001	7.40	−14 −14 −16	Midbrain
			<0.001	7.31	6 −34 −36	Pons
			<0.001	7.16	6 −20 −38	Pons
			<0.001	6.92	10 −32 −10	Right hippocampus
			<0.001	6.88	−8 −42 −48	Medulla
			<0.001	6.26	−4 −4 −2	Hypothalamus
5	0.006	1150	<0.001	7.37	−2 58 −14	Left medial orbitofrontal cortex
			<0.001	6.75	−10 14 −22	Left superior orbitofrontal cortex
			<0.001	6.34	−42 48 −10	Left inferior orbitofrontal cortex

Abbreviations: BMI, body mass index; CB₁R, cannabinoid 1 receptor; FID, food intake disorder; FWE-corr, family-wise error corrected for multiple comparisons; T, peak voxel t-statistic; K_E, cluster size extent; MNI, Montreal Neurological Institute.

The location and t-statistic of the local maxima of brain regions showing significant inverse correlations between log BMI and CB₁R availability are presented (thresholded at P_{FWE-corrected}<0.05, both at the voxel and cluster levels (T>4.2).

^aCluster also overlaps with nucleus accumbens.