Table 3. Peak voxels of brain areas where CB₁R availability covaries negatively with log BMI in healthy controls.

Cluster	Cluster level		Voxel level			Peak voxel MNI coordinates	Anatomical localization
	PFWE-corr	kE	PFWE-corr	T	Puncorr	x y z
1	0.031	129	0.002	5.01	<0.001	10 16 6	Right caudate nucleus
2	0.028	168	0.006	4.74	<0.001	0 -32 -44	Pons/medulla
3	0.041	35	0.01	4.58	<0.001	-8 18 6	Left caudate nucleus
4	0.032	118	0.024	4.29	<0.001	-2 -8 -2	Hypothalamusa
5	0.043	24	0.029	4.21	<0.001	36 -18 16	Right insula

Abbreviations: BMI, body mass index; CB₁R, cannabinoid 1 receptor; FWE-corr, family-wise error corrected for multiple comparisons; T, peak voxel t-statistic; K_E, cluster size extent; MNI, Montreal Neurological Institute.

The location and t-statistic of the local maxima of brain regions showing significant inverse correlations between log BMI and CB₁R availability are presented (thresholded at P_{FWE-corrected}<0.05, both at the voxel and cluster levels (T>4.02)).

^aCluster also overlaps with the midbrain.