Table 2. Df(h15q13)−/− fraction of all animals at weaning and survival into adulthood depends on weaning conditions.
Condition |
At weaning |
Adulthood |
|||||
---|---|---|---|---|---|---|---|
Total | −/− | −/− Fraction | Total | −/− | −/− Fraction | Binomial test | |
Weaning at 3 weeks | 162 | 19 | 0.117 | 147 | 6 | 0.041 | P<0.001 |
Weaning at 4 weeks | 101 | 12 | 0.119 | 98 | 11 | 0.112 | P>0.05 |
Weaning at 4 weeks+supplements | 403 | 50 | 0.124 | 399 | 50 | 0.125 | P>0.05 |
At weaning: genotyping at weaning, 3 or 4 weeks after birth. Df(h15q13)−/− fraction compared with birth ratio by binomial test (birth ratio was 0.20). Adulthood: 8 weeks. Total: total number of mice. −/−: number of Df(h15q13)−/− mice. −/− fraction: Df(h15q13)−/− fraction of mice compared with fraction at weaning by binomial test. Supplements: nutritional supplements were added to the breeding cages. Pairwise testing probability of survival into adulthood assuming binomial numbers and using an approximate Gaussian test: weaning at 3 weeks vs weaning at 4 weeks P<0.05, weaning at 3 weeks vs weaning at 4 weeks+supplements P<0.01, weaning at 4 weeks vs weaning at 4 weeks+supplements P>0.05.