Table 3. Behavioral phenotypes expressed qualitatively compared with WT, which is designated ‘0’.
| WT | +/- | -/- | |
|---|---|---|---|
| Early-stage seizure | 0 | + | ++ |
| Myoclonic jerks | 0 | +* | 0 |
| Clonic seizure | 0 | −* | −− |
| Repetitive jumping | 0 | (+) | ++ |
| Social preference | 0 | (+) | ++ |
| Ultrasonic vocalization | 0 | (−)* | −− |
| Nest building | 0 | − | −− |
| Acoustic startle response | 0 | − | −− |
| Prepulse inhibition | 0 | (−) | −− |
| Cue test (fear conditioning) | 0 | (−) | −− |
Abbreviation: WT, wildtype.
Decrease or increase in the Df(h15q13)+/− compared with WT, is indicated as ‘−’ or ‘+’, respectively. Changes that are not statistically significant are indicated in brackets. Stronger decrease or increase in the Df(h15q13)−/− than Df(h15q13)+/− is indicated as ‘—’ or ‘++’, respectively. ‘*’ previous reports show a significant change in the same direction for Df(h15q13)+/− mice compared with WT.