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. 2016 Jul 19;6(7):e858. doi: 10.1038/tp.2016.126

Table 2. Summary of methodological details and materials.

  Study characteristics
N (whereof female) 76 (41)
Mean age (s.d.) 25 (3.5)
Reimbursement 50€
Day 1 (trials per CS type) Habituation (7), acquisition (14)
Day 2 (trials per CS type) Extinction (14), RI-test (7)
Visual material CS 2 Gray fractals (340 × 320 pixel) × presented for 6–8 s (mean: 7 s)
Visual material ITI White fixation cross-presented for 10–16 s (mean: 13 s)
US type Digitimer DS7A constant current stimulator (Digitimer, Elwyn Garden City, UK) to the back of the right hand with a 1-cm diameter surface electrode with a platinum pin (Specialty Developments, Bexley, UK). It consisted of three 10-ms rectangular pulses with an interpulse interval of 50 ms
Reinforcement ratio 100%
RI background Cue background (grey screen without fixation cross)
N RI USs 3
Time gap last CSext−first USri 30 s
Time gap between USs 5 s
Time gap last USri−first CSri-test 13 s
Time gap RI context onset and RI 5 s
Dependent measures SCR, BOLD response (fMRI), ratings
Subjective ratings Fear/stress/tension ratings (most recent encountera) on a 25 stepped VAS (anchored at 0 and 100), retrospectively after each experimental phase
Questionnaires STAI-S, STAI-T30 and NEO-FFI31

Abbreviations: BOLD, Blood-oxygen-level dependent; CS, conditioned stimulus; fMRI, functional magnetic resonance imaging; NEO-FFI, NEO Five-Factor Inventory; RI, reinstatement; SCR, skin conductance response; STAI-S, State-Trait Anxiety Inventory - state; STAI-T, State-Trait Anxiety Inventory - trait; US, unconditioned stimulus; VAS, visual analogue scale.

a

Except for after RI-test where also the first presentation after RI was retrospectively rated.