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. 2017 Jan 3;7(1):e989. doi: 10.1038/tp.2016.249

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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DNA hypomethylation of DMR upstream of the PSORS1C3 non-coding gene. (a) Idiogram of chromosome 6 with genomic coordinates of DMR illustrated. The DMR—spanning 13 CpG sites—overlaps a CpG island (shown in blue). (b) PSORS1C3-associated DMR is hypomethylated across all 13 CpG sites in MDD suicide cases compared with controls in both brain regions. (c) Consistent with our findings, we observed DNA hypomethylation across all CpG sites present in the DMR in suicide cases compared with non-suicide controls in an independent suicide brain replication cohort. Two CpG sites (*) within the DMR were significantly differentially methylated between cases and controls (cg26818629 (P=0.03); cg26668675 (P=0.04)). DMR, differentially methylated region; MDD, major depressive disorder.