Table 2. Mean biomarker values in CSF by levels of Amyloid β (42).
| CSF biomarker (pg ml−1) | Aβ42⩽530 pg ml−1 (n=43) | Aβ42>530 pg ml−1 (n=86) |
|---|---|---|
| p-Tau | 83.6 (25.5) | 65.2 (19.7)* |
| Total tau | 609.1(230.4) | 428.2 (163.6)* |
| NFL | 1 847. (987.2) | 1940 (1353) |
| Neurogranin | 889.3 (414.5) | 686.1 (322.8)* |
| VILIP-1 | 0.13 (0.06) | 0.12 (0.05) |
| YKL-40 | 303.3 (92.2) | 274.4 (89.2) |
| FABP3 | 7.9 (2.8) | 7.2 (2.7)* |
| BDNF | 12 593 (3876) | 12 824 (4175 ) |
| VEGF | 1.8 (0.5) | 1.9 (0.5) |
| MBP | 1.8 (0.5) | 1.7 (0.5) |
| Orexin A | 691.1 (159.4) | 724.1 (189.4) |
Abbreviations: Aβ42, amyloid β (42); BDNF, brain-derived neurotrophic factor; CSF, cerebrospinal fluid; FABP3, fatty acid binding protein-3; MBP, myelin basic protein; NFL, neurofilament light; p-tau, tau phosphorylated at 181; VEGF, vascular endothelial growth factor; VILIP-1, visinin-like protein 1; YKL-40, also called chitinase 3-like 1.
Values are provided as mean (s.d.) in pg ml−1 for all CSF protein biomarkers except for VILIP-1 where levels are presented as ng ml−1. *P-value <0.05 using Mann Whitney U-Test comparing those with high Aβ42 (>530 pg/ml) and low CSF Aβ42 (⩽ 530 pg ml−1).