Table 3. Selected CSF biomarker mean values by plague pathology within APOEε4 carrier and non-carrier group.
| CSF biomarker |
APOEε4 non-carriers |
APOEε4 carriers |
||
|---|---|---|---|---|
| Aβ42⩽530 (n=18) | Aβ42>530 (n=74) | Aβ42⩽530 (n=22) | Aβ42>530 (n=12) | |
| p-tau | 90.2 (23) | 64.5 (20.4) | 77.5 (27.4) | 69.7 (14.3) |
| total tau | 673.2 (218.7) | 423.1 (167.5) | 550.8 (229.9) | 459.1 (139.8) |
| FABP3 | 8.7 (3.0) | 7.1 (2.9) | 7.4 (2.6) | 7.2 (1.7) |
| YKL-40 | 309.1 (65.2) | 272.9 (92.9) | 299.9 (109.1) | 283.7 (64.1) |
| VILIP-1 | 0.15 (0.06) | 0.12 (0.05) | 0.12 (0.06) | 0.14 (0.05) |
| neurogranin | 954.1 (349.3) | 688.6 (331.1) | 830.1 (480) | 670.9 (280.3) |
Abbreviations: CSF, cerebrospinal fluid; FABP3, fatty acid binding protein-3; p-tau, tau phosphorylated at 181; VILIP-1, visinin-like protein 1; YKL-40, also called chitinase 3-like 1.
Values are provided as mean (s.d.) in pg ml−1 for all CSF protein biomarkers except for YKL-40, VILIP-1 and FABP3, which are presented as ng ml−1. Among APOE ε4 non-carriers, significantly higher CSF levels of total tau (P<0.001), p-tau (P<0.001), neurogranin (P=0.005), YKL-40 (P=0.042), FABP3 (P=0.005) and VILIP-1 (P=0.006) were found in those biomarker positive for amyloid pathology.