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. 2017 Jan 3;7(1):e992. doi: 10.1038/tp.2016.256

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Cue-related activity to gambling>gambling-matched neutral contrast in the gambling disorder group. We observed three clusters of activity that showed a relative activity increase for gambling cues compared with gambling-matched neutral cues. An extensive cluster (covering 57 425 voxels in 2 mm standard space) extended to multiple brain regions, and so we report local maxima (Z>6.5). Peaks were localized to the left (−2, −42, 28, Z=7.14) and right (−4, −32, 32, Z=6.75) posterior cingulate gyrus, the left superior frontal gyrus (−2, 46, 50, Z=7.08), the left frontal pole ((−4, 50, 46, Z=7.01) and (−4, 58, 4, Z=6.81)) and the left paracingulate gyrus (−12, 50, 12, Z=6.54). Two smaller clusters showed peaks within the left angular gyrus (−52, −52, 40, Z=6.33) and the right lateral occipital cortex (62, −58, 34, Z=4.09). All images cluster corrected, Z>2.3, P<0.05 and presented using radiological convention.