Table 1. GVs with the lowest or highest variability in the five ethnic populations.
GWAS rank | Index SNP | Chr |
MAF |
Variability index | |||||
---|---|---|---|---|---|---|---|---|---|
EAS | EUR | AFR | AMR | SAS | |||||
GVs with the lowest variability | |||||||||
35 | rs36068923 | 8 | G | 0.189 | 0.192 | 0.256 | 0.183 | 0.194 | 1.07 |
28 | chr3_180594593_I | 3 | I | 0.170 | 0.218 | 0.316 | 0.183 | 0.257 | 1.34 |
128 | chr5_140143664_I | 5 | I | 0.473 | 0.467 | 0.689 | 0.435 | 0.481 | 1.43 |
62 | chr2_146436222_I | 2 | I | 0.095 | 0.185 | 0.163 | 0.101 | 0.096 | 1.60 |
97 | rs12148337 | 15 | T | 0.534 | 0.482 | 0.729 | 0.483 | 0.529 | 1.67 |
88 | rs7819570 | 8 | T | 0.103 | 0.199 | 0.261 | 0.120 | 0.197 | 1.73 |
93 | rs832187 | 3 | C | 0.532 | 0.402 | 0.676 | 0.370 | 0.370 | 1.75 |
68 | rs77149735 | 1 | A | 0 | 0.022 | 0.004 | 0.010 | 0.003 | 1.85 |
84 | rs1106568 | 4 | G | 0.267 | 0.250 | 0.341 | 0.206 | 0.416 | 1.99 |
122 | rs7267348 | 20 | C | 0.238 | 0.267 | 0.388 | 0.291 | 0.257 | 1.99 |
GVs with the highest variability | |||||||||
42 | rs7432375 | 3 | A | 0.791 | 0.435 | 0.041 | 0.594 | 0.508 | 9.46 |
44 | rs111294930 | 5 | G | 0.004 | 0.281 | 0.013 | 0.285 | 0.300 | 8.65 |
83 | rs59979824 | 2 | A | 0.412 | 0.336 | 0.023 | 0.458 | 0.242 | 7.98 |
114 | rs12421382 | 11 | T | 0.232 | 0.344 | 0.017 | 0.398 | 0.206 | 7.45 |
34 | rs9607782 | 22 | A | 0.056 | 0.265 | 0.152 | 0.497 | 0.327 | 7.44 |
45 | rs2973155 | 5 | T | 0.596 | 0.359 | 0.079 | 0.460 | 0.493 | 7.23 |
11 | rs4702 | 15 | G | 0.475 | 0.437 | 0.059 | 0.411 | 0.501 | 7.14 |
22 | rs12129573 | 1 | A | 0.203 | 0.397 | 0.108 | 0.542 | 0.321 | 7.03 |
18 | rs11693094 | 2 | T | 0.500 | 0.422 | 0.061 | 0.429 | 0.404 | 7.02 |
12 | rs75968099 | 3 | T | 0.055 | 0.363 | 0.060 | 0.323 | 0.321 | 6.96 |
Abbreviations: AFR, African; AMR, American; Chr, chromosome; EAS, East Asian; EUR, European; GV, genetic variant; GWAS, genome-wide association study; I, insertion; MAF, minor allele frequency; SAS, South Asian; SNP, single-nucleotide polymorphism.