Table 2. High and low genetic variability between the EAS and EUR populations.
| GWAS rank | Index SNP | Chr | A12 |
GWAS PGC-II |
Population genetics |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Frqcase | Frqcontrol | OR (95% CIs) | P | Frq EAS | Frq EUR | OR (95% CIs) | P | ||||
| High genetic variability | |||||||||||
| 72 | rs4330281 | 3 | TC | 0.479 | 0.48 | 0.94 (0.92–0.96) | 4.64 × 10−9 | 0.023 | 0.519 | 0.02 (0.01–0.03) | 1.55 × 10−138 |
| 96 | rs8082590 | 17 | AG | 0.611 | 0.614 | 0.94 (0.92–0.96) | 1.77 × 10−8 | 0.095 | 0.623 | 0.06 (0.05–0.08) | 1.10 × 10−134 |
| 74 | rs2693698 | 14 | AG | 0.412 | 0.418 | 0.94 (0.92–0.96) | 4.80 × 10−9 | 0.032 | 0.466 | 0.04 (0.03–0.05) | 1.31 × 10−112 |
| 58 | rs4766428 | 12 | TC | 0.481 | 0.474 | 1.07 (1.05–1.09) | 1.40 × 10−9 | 0.917 | 0.453 | 13.25 (10.22–17.33) | 5.14 × 10−111 |
| 15 | rs8042374 | 15 | AG | 0.75 | 0.725 | 1.09 (1.07–1.12) | 2.44 × 10−13 | 0.267 | 0.759 | 0.12 (0.09–0.14) | 2.36 × 10−108 |
| 110 | rs4388249 | 5 | TC | 0.212 | 0.213 | 1.08 (1.05–1.10) | 3.05 × 10−8 | 0.622 | 0.154 | 9.02 (7.26–11.26) | 5.89 × 10−103 |
| 112 | rs11740474 | 5 | AT | 0.601 | 0.621 | 0.94 (0.92–0.96) | 3.15 × 10−8 | 0.952 | 0.588 | 13.96 (10.15–19.59) | 5.05 × 10−84 |
| 37 | rs2514218 | 11 | TC | 0.31 | 0.314 | 0.93 (0.91–0.95) | 2.75 × 10−11 | 0.031 | 0.352 | 0.06 (0.04–0.09) | 5.18 × 10−75 |
| 44 | rs111294930 | 5 | AG | 0.788 | 0.782 | 1.09 (1.06–1.12) | 1.06 × 10−10 | 0.996 | 0.719 | 98.03 (37.64–363.52) | 6.71 × 10−71 |
| 12 | rs75968099 | 3 | TC | 0.346 | 0.324 | 1.09 (1.06–1.11) | 1.05 × 10−13 | 0.055 | 0.363 | 0.10 (0.07–0.14) | 5.29 × 10−65 |
| Low genetic variability | |||||||||||
| 75 | rs2332700 | 14 | CG | 0.262 | 0.249 | 1.07 (1.05–1.10) | 4.86 × 10−9 | 0.246 | 0.247 | 1.00 (0.81–1.23) | 9.80 × 10−1 |
| 35 | rs36068923 | 8 | AG | 0.787 | 0.803 | 0.92 (0.90–0.94) | 2.61 × 10−11 | 0.811 | 0.808 | 1.02 (0.81–1.28) | 8.93 × 10−1 |
| 17 | rs10791097 | 11 | TG | 0.479 | 0.46 | 1.08 (1.06–1.10) | 1.09 × 10-12 | 0.477 | 0.474 | 1.01 (0.85–1.21) | 8.92 × 10−1 |
| 98 | rs12325245 | 16 | AT | 0.849 | 0.859 | 0.92 (0.89–0.95) | 1.87 × 10-8 | 0.851 | 0.847 | 1.03 (0.80–1.33) | 7.89 × 10−1 |
| 128 | chr5_140143664_I | 5 | I12D | 0.486 | 0.475 | 1.06 (1.04–1.08) | 4.85 × 10-8 | 0.473 | 0.467 | 1.02 (0.86–1.23) | 7.87 × 10−1 |
| 9 | rs2851447 | 12 | CG | 0.723 | 0.741 | 0.92 (0.89–0.94) | 1.86 × 10-14 | 0.734 | 0.724 | 1.05 (0.86–1.29) | 5.97 × 10−1 |
| 120 | rs6670165 | 1 | TC | 0.196 | 0.184 | 1.08 (1.05–1.10) | 4.45 × 10-8 | 0.19 | 0.201 | 0.94 (0.75–1.17) | 5.59 × 10−1 |
| 65 | rs1498232 | 1 | TC | 0.311 | 0.296 | 1.07 (1.05–1.09) | 2.86 × 10-9 | 0.295 | 0.307 | 0.94 (0.78–1.15) | 5.40 × 10−1 |
| 77 | rs6984242 | 8 | AG | 0.586 | 0.6 | 0.94 (0.92–0.96) | 5.97 × 10-9 | 0.617 | 0.603 | 1.06 (0.88–1.27) | 5.29 × 10−1 |
| 84 | rs1106568 | 4 | AG | 0.747 | 0.761 | 0.93 (0.91–0.96) | 9.47 × 10-9 | 0.733 | 0.75 | 0.91 (0.74–1.12) | 3.73 × 10−1 |
Abbreviations: Chr, chromosome; CI, confidence interval; D, deletion; EAS, East Asian; EUR, European; Frq, frequency; GWAS, genome-wide association study; I, insertion; OR, odds ratio; PGC, Psychiatric Genomics Consortium; SNP, single-nucleotide polymorphism.
Significant P-values are shown in boldface and underlined.