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. 2017 Jan 17;7(1):e1001. doi: 10.1038/tp.2016.263

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Following cognitive behavioural therapy for psychosis, the change in specific social-affect functional connections differentially predicts level of positive psychotic symptoms (top) and affective symptoms (bottom) across eight years. Top: the increase in connectivity between dorsolateral prefrontal cortex (DLPFC) and postcentral gyrus when processing prosocial facial affect predicted reduced levels of positive psychotic symptoms (r_ρ(15)=0.495, P=0.06). Bottom: conversely, the increase in amygdala connectivity with the inferior parietal lobule (IPL) when processing social threat predicted reduced levels of affective symptoms (r_ρ(15)=0.49, P=0.06). Dotted lines between brain regions represent connectivity.