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. 2017 Jan 17;7(1):e1002. doi: 10.1038/tp.2016.275

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Illustration of cell-type composition effect using principal component analysis (PCA). The heatmap indicates significant correlations between the first two principal components and the estimations of blood cell types. After cell-type correction, no association between the first two principal components and cell type are longer observed. Bcell, B cell; Gran, granulocyte; Mono, monocytes; NK, natural killer; PC, principal component.