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. 2017 Jan 17;7(1):e1005. doi: 10.1038/tp.2016.276

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The alterations in amygdala–PFC functional connectivity (FC) development in maltreated (abused) animals. Nearly significant group by age interactions were found on basal amygdala—prelimbic PFC FC (a) and lateral amygdala—ACC FC (b). In controls, amygdala–PFC FC increased from adolescence to adulthood *(P<0.06), whereas maltreated animals did not change significantly. FC between lateral amygdala and ACC was significantly lower in maltreated adult rats than in control adults (P<0.05). Bars show means and error bars represent s.e.m. ACC, anterior cingulate cortex; PFC, prefrontal cortex.