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. 2017 Mar 2;102(2):321–331. doi: 10.1002/cpt.634

Figure 3.

Figure 3

Relation between rifapentine area under the concentration–time curve (AUC) from 0 to 24 h (AUC0‐24) vs. dose (900 or 1,200 mg) and food type (high fat (hf), >27 g fat; lower fat (lf), 1 to 27 g fat; or fasting (fast)). Target rifapentine AUC0‐24 needed for 95% participants with no or small (<4 cm) lung cavities at baseline radiograph to achieve persistently negative cultures (AUC95) in liquid media indicated by the green horizontal line. Insufficient exposure indicated by the red line. Model estimates of rifapentine AUC95 and Figure 1 were used to formulate target cutoffs of rifapentine AUC0‐24 >350 μg × h/mL and low target rifapentine AUC0‐24 of <300 μg × h/mL using sputa cultures in liquid media.