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. Author manuscript; available in PMC: 2017 Aug 7.
Published in final edited form as: Curr Top Dev Biol. 2015 Oct 21;115:111–130. doi: 10.1016/bs.ctdb.2015.07.029

Figure 1. Fgf10 is essential for SMG epithelial development.

Figure 1

Whole mount immunostaining of an E12 wildtype (Fgf10+/+) SMG and Fgf10−/− SMG mesenchyme. SMG development involves the formation of an epithelial endbud and primary duct (E-Cadherin, green) within a condensed mesenchyme, which is surrounded by an endothelial cell plexus (PCAM, cyan blue) and the formation of a PSG (Tubb3, red). White dotted lines outline PSG, white dashed line is the oral epithelium (oral ep); arrows indicate nerves in the adjacent tongue and oral epithelium. Scale bar, 50 μm. From Figure 2B in Knosp et al., 2015.