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Claudin functional domains and key binding partners that mediate intestinal epithelial homeostasis. (A) In the colon, a single layer of epithelial cells is organized in crypts. (B) Schematic representation of claudin functional domains and their key binding partners in the tight junction. IEC, intestinal epithelial cells; TJ, tight junction; EC, extracellular loop; PTMr, posttranslational modifications region; PDZbm, PDZ binding motif.
