Table 1.

Claudin expression in the colon during IBD (Crohn’s disease and ulcerative colitis) and experimental colitis murine models.

Claudin	Function/permeability properties	Experimental colitis in mice	IBD samples
			UC	CD
1	Cation barrier35	↑120	↑86,119	↑86
2	Cation pore and paracellular water channel37,43,61	–	↑25,86,118	↑26,86
3	Cation barrier15	–	↓25	↓25
4	Cation barrier36	–	↓25,86	–
5	Cation barrier37	–	–	↓26
7	Anion barrier and pore38,39,40	–	↓86	–
8	Cation barrier54	–	–	↓26
12	Barrier		–	↓74
18	Barrier15	↑ TNBS127	↑128	–

NOTE: UC, ulcerative colitis; CD, Crohn’s disease; TNBS, trinitrobenzenesulfonic acid.