. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Ann N Y Acad Sci. 2017 May 10;1397(1):66–79. doi: 10.1111/nyas.13360

Table 2.

Cytokine effects on claudin expression in IEC lines.

Cytokine	Claudin expression	Cells	References
TNF-α	↑ Claudin-1	IEC-18	¹¹⁹
TNF-α	↑ Claudin-2	HT-29/B6	¹⁰⁰
TNF-α	↓ Claudin-2	T84	¹³⁴
TNF-α	No change in claudin-2	T84	¹²⁹
INFγ + TNF-α	↓ Claudin-2 ↓ Claudin-3	T84	²⁵
IL-1β	↑ Claudin-1 ↓ Occludin	Caco-2	¹³²
IL-4	↑ Claudin-2	T84	¹³⁴
IL-6	↑ Claudin-2	Caco-2	¹³¹
IL-6	↑ Claudin-2	Caco-2	¹³³
IL-13	↑ Claudin-2	T84	¹²⁹
IL-13	↑ Claudin-2 ↑ Claudin-4	T84	²⁵
IL-17	↑ Claudin-1 mRNA ↑ Claudin-2 mRNA	T84	¹³⁰

Cell lines: HT-29/B6 and Caco-2, human colorectal carcinoma; IEC-18, non transformed small intestine; T84, colorectal carcinoma form lung metastasis.