Table 2.
Parameter | TDF permeation from non-everted intestine sac |
TDF permeation from everted intestine sac |
||||||
---|---|---|---|---|---|---|---|---|
Absence of enzyme |
Presence of enzyme |
Absence of enzyme |
Presence of enzyme |
|||||
TDF solution | TDF loaded LCP | TDF solution | TDF loaded LCP | TDF solution | TDF loaded LCP | TDF solution | TDF loaded LCP | |
Permeation flux (%/h) | 3.41 ± 0.21 | 17.45 ± 1.34** | 3.62 ± 0.37 ns | 21.86 ± 1.0** | 3.07 ± 1.03 | 11.94 ± 1.28** | 3.70 ± 1.34 ns | 16.86 ± 1.34** |
Apparent permeation coefficient (cm/h)2 | 2.17 ± 1.04 | 11.11 ± 2.2** | 2.3 ± 1.11 ns | 13.91 ± 2.31** | 1.95 ± 1.27 | 7.6 ± 1.57** | 2.35 ± 1.18 ns | 10.73 ± 1.84** |
Mean ± SD. Data analyzed by one way ANOVA followed by posthoc Dunnett’s test, with *P < 0.05 considered significant, **P < 0.01, ns – nonsignificant, n = 3.