Table 1.
Gene ontology analysis of aberrantly methylated-differentially expressed genes in colorectal cancer
| Category | GO analysis | Term | Gene count | % | P value |
|---|---|---|---|---|---|
| Hypomethylation and high expression | |||||
| GOTERM_BP_FAT | GO:0009611~response to wounding | 37 | 9.00 | 9.44E−08 | |
| GOTERM_BP_FAT | GO:0006954~inflammatory response | 25 | 6.08 | 3.48E−06 | |
| GOTERM_BP_FAT | GO:0008283~cell proliferation | 29 | 7.06 | 7.95E−06 | |
| GOTERM_BP_FAT | GO:0007155~cell adhesion | 37 | 9.00 | 5.54E−05 | |
| GOTERM_BP_FAT | GO:0022610~biological adhesion | 37 | 9.00 | 5.55E−05 | |
| GOTERM_CC_FAT | GO:0005576~extracellular region | 92 | 22.38 | 2.01E−08 | |
| GOTERM_CC_FAT | GO:0044421~extracellular region part | 55 | 13.38 | 3.78E−08 | |
| GOTERM_CC_FAT | GO:0005615~extracellular space | 42 | 10.22 | 4.12E−07 | |
| GOTERM_CC_FAT | GO:0005578~proteinaceous extracellular matrix | 21 | 5.11 | 2.45E−04 | |
| GOTERM_CC_FAT | GO:0005625~soluble fraction | 20 | 4.87 | 5.01E−04 | |
| GOTERM_MF_FAT | GO:0042802~identical protein binding | 35 | 8.52 | 8.25E−05 | |
| GOTERM_MF_FAT | GO:0005125~cytokine activity | 15 | 3.65 | 6.69E−04 | |
| GOTERM_MF_FAT | GO:0004175~endopeptidase activity | 21 | 5.11 | 2.33E−03 | |
| GOTERM_MF_FAT | GO:0030674~protein binding, bridging | 9 | 2.19 | 3.39E−03 | |
| GOTERM_MF_FAT | GO:0008201~heparin binding | 9 | 2.19 | 5.90E−03 | |
| Hypermethylation and low expression | |||||
| GOTERM_BP_FAT | GO:0007267~cell–cell signaling | 29 | 12.13 | 3.32E−07 | |
| GOTERM_BP_FAT | GO:0019226~transmission of nerve impulse | 18 | 7.53 | 4.70E−05 | |
| GOTERM_BP_FAT | GO:0031644~regulation of neurological system process | 11 | 4.60 | 1.72E−04 | |
| GOTERM_BP_FAT | GO:0007610~behavior | 20 | 8.37 | 1.90E−04 | |
| GOTERM_BP_FAT | GO:0030182~neuron differentiation | 19 | 7.95 | 2.35E−04 | |
| GOTERM_CC_FAT | GO:0044459~plasma membrane part | 64 | 26.78 | 2.13E−09 | |
| GOTERM_CC_FAT | GO:0005886~plasma membrane | 84 | 35.15 | 5.38E−07 | |
| GOTERM_CC_FAT | GO:0043005~neuron projection | 19 | 7.95 | 1.13E−06 | |
| GOTERM_CC_FAT | GO:0005887~integral to plasma membrane | 38 | 15.90 | 1.67E−06 | |
| GOTERM_CC_FAT | GO:0031226~intrinsic to plasma membrane | 38 | 15.90 | 2.85E−06 | |
| GOTERM_MF_FAT | GO:0003700~transcription factor activity | 38 | 15.90 | 2.48E−07 | |
| GOTERM_MF_FAT | GO:0022836~gated channel activity | 16 | 6.69 | 9.15E−05 | |
| GOTERM_MF_FAT | GO:0015267~channel activity | 18 | 7.53 | 2.17E−04 | |
| GOTERM_MF_FAT | GO:0022803~passive transmembrane transporter activity | 18 | 7.53 | 2.23E−04 | |
| GOTERM_MF_FAT | GO:0005216~ion channel activity | 17 | 7.11 | 3.17E−04 | |