Table 2.
KEGG pathway analysis of aberrantly methylated-differentially expressed genes in colorectal cancer
| Pathway ID | Pathway name | Gene no. | % | P value | Genes |
|---|---|---|---|---|---|
| Hypomethylation and high expression | |||||
| hsa04060 | Cytokine–cytokine receptor interaction | 20 | 4.87 | 5.86E−04 | CXCL1, IL2RA, LTBR, CXCL3, IL21R, CXCL2, MET, CXCL9, TNFSF15, TNFRSF4, CCL18, LIF, INHBA, TNFRSF9, TNFSF11, IL23A, PRLR, CCL20, IL20RA, ACVR1 |
| hsa04115 | p53 signaling pathway | 8 | 1.95 | 5.54E−03 | CCND1, SERPINB5, CD82, RRM2, TSC2, CASP8, PMAIP1, ATM |
| hsa04110 | Cell cycle | 9 | 2.19 | 0.045 | CCND1, PKMYT1, PRKDC, RB1, CDC16, CDC27, ATM, WEE1, TFDP1 |
| Hypermethylation and low expression | |||||
| hsa04020 | Calcium signaling pathway | 12 | 5.02 | 7.80E−04 | EGFR, EDNRB, ADCY2, PTGER3, PDE1B, PDE1C, DRD5, GRIN2A, PLCD1, ITPKB, CAMK2B, PTGFR |
| hsa04950 | Maturity onset diabetes of the young | 5 | 2.09 | 1.45E−03 | HHEX, NEUROD1, HNF4G, NEUROG3, NKX2-2 |
| hsa04514 | Cell adhesion molecules (CAMs) | 8 | 3.35 | 0.017 | NCAM1, CD8A, ITGA8, NLGN4X, CNTN1, ITGA4, JAM2, HLA-G |
| hsa04080 | Neuroactive ligand-receptor interaction | 11 | 4.60 | 0.033 | EDNRB, SSTR2, PTGER3, GABRB3, GRIK1, GRIK2, DRD5, GRIN2A, GRIA3, PTGFR, VIPR2 |
| hsa04062 | Chemokine signaling pathway | 9 | 3.77 | 0.035 | DOCK2, ADCY2, CXCL14, TIAM1, HCK, PIK3CD, CCR10, RAP1A, ELMO1 |
| hsa04666 | Fc gamma R-mediated phagocytosis | 6 | 2.51 | 0.043 | DOCK2, HCK, PIK3CD, ARF6, AMPH, DNM2 |