Table 1.

PHASE 3 Judging risk of bias

Domain	Concern	Rationale for concern
Concerns regarding specification of the study eligibility criteria	Non –confirmed cases	Decrease the risk of bias (false positive)
Concerns regarding methods used to identify and/or select studies.	None	None
Concerns regarding used to collect data and appraise the studies	Repeated article	Increase the false positive results
Concerns regarding the synthesis and findings	Different finding between the article	To direct the results toward the major finding and analyzed it
Describe whether conclusions were supported by the evidence:
A. Did the interpretation of findings address all of the concerns identified in Domain 1 to 4?		Yes
B. Was the relevance of identified studies to the review’s research question appropriately considered?		Probably yes
C. Did the reviewers avoid emphasizing results on the basis of their statistical significance?		Yes
Risk of bias in the review		Risk: Low