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In vitro cytotoxicity of DOX, T1k2k, T1k2k-TOS, and T1k2k-TOS-DOX micelles against (A) MCF-7 and (B) MCF-7/Adr cells after 48 h of treatment. Data are presented as mean ± SD (n = 5). (C) Colony formation assays of MCF-7 and MCF-7/Adr cells. The histogram represents the number of colonies of MCF-7 and MCF-7/Adr cells after 7 days of treatment. Colonies of more than 50 cells were counted.
