b)
Parameter	Hazard ratio	p value
	(95% Confidence Interval)
Age per year	1.015 (0.997– 1.034)	0.093
Instillation therapy yes vs. no	0.484 (0.317– 0.738)	0.001
Ki-67 expression ≥50% vs. < 50%	2.553 (1.779– 3.664)	<0.001

Abbreviations: CI: confidence interval. Bold value significant is p < 0.05.