Table 2.

Mean and SD of fixation stability, pro-saccade, and smooth pursuit metrics for young onset Alzheimer’s disease (YOAD) patients and age-matched healthy controls.

		YOAD	Controls
		Mean (SD)	Mean (SD)
Fixation stability
Number of large intrusive saccades		2.5 (4.3)*	0.7 (1.7)*
Number of square wave jerks		0.9 (1.6)	0.9 (1.6)
Maximum fixation duration (ms)		1,950.7 (1,352.8)*	2,908.5 (2,062.1)*
Pro-saccade
Accuracy	Overall	0.85 (0.35)*	0.94 (0.24)*
	5°	0.90 (0.31)	0.96 (0.19)
	10°	0.84 (0.37)*	0.92 (0.27)*
	15°	0.81 (0.39)*	0.93 (0.26)*
	Up	0.86 (0.35)	0.90 (0.30)
	Down	0.86 (0.32)*	0.93 (0.22)*
	Right	0.83 (0.38)*	0.97 (0.18)*
	Left	0.86 (0.35)	0.93 (0.25)
Time taken to reach the target (ms)	Overall	538.7 (682.3)*	328.7 (329.8)*
	5°	437.1 (583.0)*	306.1 (366.6)*
	10°	613.8 (777.3)*	337.4 (333.4)*
	15°	609.0 (650.4)*	358.8 (222.9)*
	Up	537.8 (648.5)*	365.6 (468.4)*
	Down	518.5 (571.2)*	329.2 (163.4)*
	Right	591.0 (827.1)*	300.6 (180.7)*
	Left	501.9 (613.8)*	333.6 (413.8)*
Saccades made to reach the target	Overall	3.1 (2.3)*	2.1 (1.2)*
	5°	2.7 (1.9)*	2.0 (1.2)*
	10°	3.4 (2.7)*	2.1 (1.1)*
	15°	3.4 (2.4)*	2.2 (1.2)*
	Up	3.3 (2.4)*	2.3 (1.3)*
	Down	3.1 (2.5)*	2.1 (1.1)*
	Right	3.0 (2.1)*	2.1 (1.2)*
	Left	3.0 (2.2)*	2.0 (1.1)*
Smooth pursuit
Pursuit gain	Overall	1.4 (0.4)	1.4 (0.4)
	10°/s	1.4 (0.3)	1.4 (0.4)
	20°/s	1.3 (0.4)	1.4 (0.4)
	Horizontal	1.3 (0.3)	1.3 (0.3)
	Vertical	1.5 (0.4)	1.4 (0.4)
Prop. of time pursuing the target	Overall	0.4 (0.2)*	0.6 (0.2)*
	10°/s	0.5 (0.2)*	0.6 (0.1)*
	20°/s	0.3 (0.2)*	0.5 (0.2)*
	Horizontal	0.5 (0.2)*	0.7 (0.1)*
	Vertical	0.3 (0.1)*	0.5 (0.1)*

Statistically significant differences are highlighted in blue and marked with an asterisk (*) (for specific p values see text).